2-Phenylnaphtho[2,3-d]oxazole-4,9-dione
SJB2-043
CAS: 63388-44-3
Molecular Formula: C17H9NO3
2-Phenylnaphtho[2,3-d]oxazole-4,9-dione - Names and Identifiers
2-Phenylnaphtho[2,3-d]oxazole-4,9-dione - Physico-chemical Properties
| Molecular Formula | C17H9NO3 |
| Molar Mass | 275.26 |
| Density | 1.373±0.06 g/cm3(Predicted) |
| Melting Point | >290℃ |
| Boling Point | 495.0±48.0 °C(Predicted) |
| pKa | -3.87±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC 50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner. |
2-Phenylnaphtho[2,3-d]oxazole-4,9-dione - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.633 ml | 18.165 ml | 36.329 ml |
| 5 mM | 0.727 ml | 3.633 ml | 7.266 ml |
| 10 mM | 0.363 ml | 1.816 ml | 3.633 ml |
| 5 mM | 0.073 ml | 0.363 ml | 0.727 ml |
Last Update：2024-01-02 23:10:35
2-Phenylnaphtho[2,3-d]oxazole-4,9-dione - Reference Information
| uses | SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with an IC50 of 544 nM. |
| biological activity | SJB2-043 is a potent inhibitor of USP1, which can inhibit the activity of natural USP1/uaf1, the corresponding IC50 value was 544 nM. |
| Target | Value |
| USP1-UAF1 (Cell-free assay) | 544 nM |
Last Update：2024-04-10 22:29:15
![2-Phenylnaphtho[2,3-d]oxazole-4,9-dione](http://res.chembk.com/assets/str/2d/6/63/63388-44-3.png)
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Product Name: SJB2-043 Visit Supplier Webpage Request for quotationCAS: 63388-44-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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